Comparison of Hormone Reference Preparations

Abbr.____	Reference Preparation	Potency	Definition of Potency
hFSH__	1st IRP-hMG (1960)	No official units	Activity as "mg" 1st IRP-hMG
	2nd IRP-hMG (1964)	40 IU/ampule	1 IU = 7mg 1st IRP-hMG
	1st IRP-Pituitary FSH/LH for Bioassay (69/104)	10 IU/ampule	Approximately 20 IU 2nd IRP-hMG
	2nd IRP-Pituitary FSH/LH for Bioassay (78/549)_____	10 IU/ampule	Based on 69/104
	1st IS-Pituitary FSH (83/575)	80 IU/ampule	5 - 80 IU (78/549), depending on assay

hGH	1st IRP (66/217)	2.2 IU/mg of pure hormone______	Equivalent to NIAMDD-hGH-RP1
	1st IS (80/505)	4.4 IU/ampule	Based on 66/217

hLH	1st IRP-hMG (1960)	No official units	Activity as "mg" 1st IRP-hMG
	2nd IRP-hMG (1964)	40 IU/ampule	1 IU = 2mg 1st IRP-hMG
	1st IRP-Pituitary FSH/LH for Bioassay (69/104)	25 IU/ampule	Approximately 50 IU 2nd IRP-hMG
	2nd IRP-Pituitary FSH/LH for Bioassay (78/549)	25 IU/ampule	Based on 69/104
	1st IRP-Pituitary LH (68/40)	77 IU/ampule	15 - 75 IU (69/104), depending on assay
	2nd IS-Pituitary LH (80/552)	35 IU/ampule	25 - 45 IU (68/40), depending on assay

hPRL	1st IRP (75/504)	30 IU/mg of pure hormone
	2nd IS (83/562)	53 mIU/ampule	53 mIU 1st IRP (75/504)
	3rd IS (84/500)	53 mIU/ampule	53 mIU 2nd IS (83/562)

hTSH	1st IRP, human TSH (68/38)	150 mIU/ampule	By definition
	2nd IRP, human TSH (80/558)	37 mIU/ampule	36 - 46 mIU (68/38), depending on assay