For several decades, Scripps Laboratories has offered the highest quality, best performing native Ferritin available anywhere. Now, we are proud to present to you our recombinant Apoferritin.
- Multi-Subunit Whole Molecule
- Heavy-Chain and Light-Chain Subunits
- No Affinity Tags
- Large, Bulk Lots
- Steady Supply
Our Recombinant Apoferritin is the multi-subunit ferritin molecule, but it does not contain any iron atoms. It has been assayed on multiple clinical analyzers and is a suitable replacement for native Liver and Spleen Ferritin. It is ≥95% pure by SDS-PAGE and it is produced without affinity tags, so the final product is the unmodified, intact protein.
Ferritin is a water-soluble, iron storage protein found in most animal cells. Its spherical structure is composed of 24 subunits and contains a 7-nm cavity with a ferric oxyhydroxide crystalline core that is capable of storing approximately 4500 iron atoms. Iron passes in and out of the ferritin cavity through 0.7-1.0 nm pores in the outer shell. Up to 25 ferritin isoforms are thought to exist, composed of various combinations of the two primary subunits, H and L, which have molecular weights of 21,000 and 19,000, respectively. Ferritin rich in the H subunit is found in heart muscle, red blood cells, lymphocytes, and monocytes, while that rich in the L subunit is found in the liver, spleen, and placenta. Ferritins composed of a higher proportion of H subunits are more acidic (pI as low as 4.8) than the isoforms containing a higher proportion of L subunits (pI 5.3-5.8) Human serum ferritin is primarily composed of the L subunit, which also corresponds with a lower iron content. Ferritin isolated from the liver and spleen contain >12% iron by weight.
Ferritin is the body's primary iron source for hemoglobin synthesis; only hemoglobin itself accounts for more of the body's total iron content. When serum iron levels decrease below normal levels, ferritin readily releases its iron stores for use. Serum levels of ferritin are known to closely parallel tissue ferritin levels and are, therefore, indicative of body iron content. As such, clinical tests for ferritin serum levels are used to detect and manage iron-related disorders, such as iron deficiency anemia and iron overload. High levels of serum ferritin are associated with disease severity in Covid-19 patients, in addition to various malignant diseases and tissue damage.
Scripps Laboratories is a world-leading producer and supplier of purified human Liver Ferritin and Spleen Ferritin. Products are prepared on-site and shipped to you directly. For Bulk Discounts or additional product information, please use the button below to send us a note.